I argue that advancing “second-generation” or mechanistic causal knowledge of individual outcomes requires a comprehensive research programme that uses a variety of different methods in addition to the ones described in the paper under discussion. I also highlight that environment-focused approaches can be as instrumental in identifying potential phenotypic causes as gene-focused approaches.

In this case report, we describe a woman with advancing dementia who still retained decisional capacity and was able to clearly articulate her request for deactivation of her implanted cardiac pacemaker—a scenario that would result in her death. In this case, the patient had the autonomy to make her decision, but clinicians at an outside hospital refused to deactivate her pacemaker even though they were in unanimous agreement that the patient had capacity to make this decision, citing personal discomfort and (...) a belief that her decision seemed out of proportion to her suffering. We evaluated her at our hospital, found her to have decision-making capacity, and deactivated her pacer resulting in her death about 9 days later. While some clinicians may be comfortable discussing patient preferences for device deactivation in patients who are imminently dying, we can find no reports in the literature of requests for device deactivation from patients with terminal diagnoses who are not imminently dying. (shrink)

Для широкого круга читателей (слушателей, аспирантов, преподавателей) интересующихся данной проблемой.

Bringing together essays that span the career of I.A. Richards--as both literary critic and pedagogue--this collection provides a much-needed re-introduction to a thinker whose works have been largely neglected of late. Carefully chosen, edited, and annotated, the selections make accessible a wide array of Richards's ideas on language and learning, focusing on his discussion of literacy, his critique of positivist linguistics, his explorations of C.S. Peirce's semiotics, and his theory of translation, which led not only to his well-known analysis of (...) the structure and foundation of metaphor but to one of the earliest and most cogent formulations of reader-response theory. Berthoff's editing eliminates the distracting elements of Richards's style--the digressions and obscure allusions that have often hindered readers, and have in part contributed to the neglect his work has met with in recent years--while identifying and illuminating the chief principles of his critical thought and practice. Organized in four parts--Practical Criticism, The Philosophy of Rhetoric, The Meaning of Meaning, and Design for Escape--the book offers a lucid introduction to Richards's writings, with valuable headnotes to each section and a unique index of "speculative instruments" that examines the principal ideas Richards thought with. Readers are certain to find this volume essential to an understanding of Richards's "practical criticism," and invaluable in sharpening and re-directing their own thoughts on current linguistic practice, literary criticism, and educational theory. (shrink)

In the English-speaking world conceptual analysis was seen for some years as the principal method of philosophizing and at times was even taken as equivalent to philosophy itself. In recent years it has come under attack as socially conservative and intellectually barren. It is my view that in many ways conceptual analysis was beneficial to philosophy: in its concern for clarity and precision it reminded us of much which philosophers must never forget. I would hope, however, that we are now (...) in a position to see it more as a tool of philosophy than as a substitute for it. (shrink)